Erythritol Functional Roles in Oral-Systemic Health.
Identifieur interne : 000088 ( Main/Exploration ); précédent : 000087; suivant : 000089Erythritol Functional Roles in Oral-Systemic Health.
Auteurs : P. De Cock [Belgique]Source :
- Advances in dental research [ 1544-0737 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- effets des médicaments et des substances chimiques : Biofilms.
- métabolisme : Édulcorants, Érythritol.
- pharmacologie : Édulcorants, Érythritol.
- prévention et contrôle : Caries dentaires.
- Humains, Santé buccodentaire.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Erythritol, Sweetening Agents.
- drug effects : Biofilms.
- chemical , pharmacology : Erythritol, Sweetening Agents.
- prevention & control : Dental Caries.
- Humans, Oral Health.
Abstract
Erythritol belongs chemically to the family of polyols (or sugar alcohols), yet it is metabolized by animals and humans very differently compared to all other polyols. While polyols have been used traditionally (for about 80 y) to replace sugar in sweet foods to reduce demineralization of tooth enamel and to reduce postprandial blood glucose levels, benefits achieved merely through the absence of sugar, emerging evidence shows that erythritol can play a number of functional roles to actively support maintenance of oral and systemic health. Oral health studies revealed that erythritol can reduce dental plaque weight, reduce dental plaque acids, reduce counts of mutans streptococci in saliva and dental plaque, and reduce the risk for dental caries better than sorbitol and xylitol, resulting in fewer tooth restorations by dentist intervention. Systemic health studies have shown that erythritol, unlike other polyols, is readily absorbed from the small intestine, not systemically metabolized, and excreted unchanged within the urine. This metabolic profile renders erythritol to be noncaloric, to have a high gastrointestinal tolerance, and not to increase blood glucose or insulin levels. Published evidence also shows that erythritol can act as an antioxidant and that it may improve endothelial function in people with type 2 diabetes. This article reviews the key research demonstrating erythritol's oral and systemic health functionalities and underlying mechanisms.
DOI: 10.1177/0022034517736499
PubMed: 29355425
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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De Cock</name><affiliation wicri:level="1"><nlm:affiliation>1 DGH Nutrition Innovation, Keerbergen, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>1 DGH Nutrition Innovation, Keerbergen</wicri:regionArea><wicri:noRegion>Keerbergen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Advances in dental research</title><idno type="eISSN">1544-0737</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biofilms (drug effects)</term><term>Dental Caries (prevention & control)</term><term>Erythritol (metabolism)</term><term>Erythritol (pharmacology)</term><term>Humans (MeSH)</term><term>Oral Health (MeSH)</term><term>Sweetening Agents (metabolism)</term><term>Sweetening Agents (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Biofilms (effets des médicaments et des substances chimiques)</term><term>Caries dentaires (prévention et contrôle)</term><term>Humains (MeSH)</term><term>Santé buccodentaire (MeSH)</term><term>Édulcorants (métabolisme)</term><term>Édulcorants (pharmacologie)</term><term>Érythritol (métabolisme)</term><term>Érythritol (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Erythritol</term><term>Sweetening Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Biofilms</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Biofilms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Édulcorants</term><term>Érythritol</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Édulcorants</term><term>Érythritol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Erythritol</term><term>Sweetening Agents</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Dental Caries</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Caries dentaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Oral Health</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Santé buccodentaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Erythritol belongs chemically to the family of polyols (or sugar alcohols), yet it is metabolized by animals and humans very differently compared to all other polyols. While polyols have been used traditionally (for about 80 y) to replace sugar in sweet foods to reduce demineralization of tooth enamel and to reduce postprandial blood glucose levels, benefits achieved merely through the absence of sugar, emerging evidence shows that erythritol can play a number of functional roles to actively support maintenance of oral and systemic health. Oral health studies revealed that erythritol can reduce dental plaque weight, reduce dental plaque acids, reduce counts of mutans streptococci in saliva and dental plaque, and reduce the risk for dental caries better than sorbitol and xylitol, resulting in fewer tooth restorations by dentist intervention. Systemic health studies have shown that erythritol, unlike other polyols, is readily absorbed from the small intestine, not systemically metabolized, and excreted unchanged within the urine. This metabolic profile renders erythritol to be noncaloric, to have a high gastrointestinal tolerance, and not to increase blood glucose or insulin levels. Published evidence also shows that erythritol can act as an antioxidant and that it may improve endothelial function in people with type 2 diabetes. This article reviews the key research demonstrating erythritol's oral and systemic health functionalities and underlying mechanisms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29355425</PMID><DateCompleted><Year>2018</Year><Month>12</Month><Day>26</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1544-0737</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>02</Month></PubDate></JournalIssue><Title>Advances in dental research</Title><ISOAbbreviation>Adv Dent Res</ISOAbbreviation></Journal><ArticleTitle>Erythritol Functional Roles in Oral-Systemic Health.</ArticleTitle><Pagination><MedlinePgn>104-109</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/0022034517736499</ELocationID><Abstract><AbstractText>Erythritol belongs chemically to the family of polyols (or sugar alcohols), yet it is metabolized by animals and humans very differently compared to all other polyols. While polyols have been used traditionally (for about 80 y) to replace sugar in sweet foods to reduce demineralization of tooth enamel and to reduce postprandial blood glucose levels, benefits achieved merely through the absence of sugar, emerging evidence shows that erythritol can play a number of functional roles to actively support maintenance of oral and systemic health. Oral health studies revealed that erythritol can reduce dental plaque weight, reduce dental plaque acids, reduce counts of mutans streptococci in saliva and dental plaque, and reduce the risk for dental caries better than sorbitol and xylitol, resulting in fewer tooth restorations by dentist intervention. Systemic health studies have shown that erythritol, unlike other polyols, is readily absorbed from the small intestine, not systemically metabolized, and excreted unchanged within the urine. This metabolic profile renders erythritol to be noncaloric, to have a high gastrointestinal tolerance, and not to increase blood glucose or insulin levels. Published evidence also shows that erythritol can act as an antioxidant and that it may improve endothelial function in people with type 2 diabetes. This article reviews the key research demonstrating erythritol's oral and systemic health functionalities and underlying mechanisms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Cock</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>1 DGH Nutrition Innovation, Keerbergen, Belgium.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Adv Dent Res</MedlineTA><NlmUniqueID>8802131</NlmUniqueID><ISSNLinking>0895-9374</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013549">Sweetening Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>RA96B954X6</RegistryNumber><NameOfSubstance UI="D004896">Erythritol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018441" MajorTopicYN="N">Biofilms</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003731" MajorTopicYN="N">Dental Caries</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004896" MajorTopicYN="N">Erythritol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009909" MajorTopicYN="Y">Oral Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013549" MajorTopicYN="N">Sweetening Agents</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Streptococcus mutans</Keyword><Keyword MajorTopicYN="Y">caries</Keyword><Keyword MajorTopicYN="Y">diabetes mellitus</Keyword><Keyword MajorTopicYN="Y">plaque biofilms</Keyword><Keyword MajorTopicYN="Y">prevention</Keyword><Keyword MajorTopicYN="Y">vascular biology</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29355425</ArticleId><ArticleId IdType="doi">10.1177/0022034517736499</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="De Cock, P" sort="De Cock, P" uniqKey="De Cock P" first="P" last="De Cock">P. 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